Lactobacillus paracasei R3 protects against dextran sulfate sodium (DSS)-induced colitis in mice via regulating Th17/Treg cell balance

Abstract Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier function, dysregulated host responses to microbial stimulation. Strategies that target microbiota have emerged as potential therapies and, of these, probiotics gained greatest attention. Herein, we isolated strain Lactobacillus paracasei R3 ( L.p R3) strong biofilm formation ability infant feces. Interestingly, also found can ameliorate general symptoms murine colitis, alleviate inflammatory cell infiltration inhibit Th17 while promote Treg function dextran sulfate sodium (DSS)-induced colitis. Overall, this study suggested significantly improves pathological damage mice influences immune by regulating Th17/Treg balance DSS-induced mice.